Neuraxonal dystrophy

From Felipedia

Neuraxonal dystrophy is described in both cats and dogs but primarily in Rottweiler dogs (autosomal recessive inheritance). In Rottweilers, the onset is between 3-24 mo of age, and the disorder progresses slowly over several years. Signs include cerebellar dysfunction and dysmetria in all 4 limbs, but with preservation of paw position sense, which should distinguish it from leukoencephalomyelopathy and from advanced motor neuron disease in the same breed. Collie dogs in Australia and New Zealand develop similar clinical signs at 2-4 mo of age.

There is also early onset in Papillons and Chihuahuas and in cats (autosomal recessive in Domestic Tricoloured cats). Axonal spheroids, often in specific regions of the brain and spinal cord, are the characteristic pathologic finding of these conditions. Associated with a pale coat colour similar to non-agouti lilac. Affected kittens show head-nodding at 5 weeks old; more pronounced head-shaking at 6 weeks and uncoordinated gait at 8 weeks. These symptoms worsen as the disease progresses. Sight and hearing may deteriorate and growth is stunted[1].