IRIS staging system

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Recently, the International Renal Interest Society (IRIS) developed a four stage system for gauging the continuum of progressive renal disease. Staging is based on the level of blood creatine as a function of renal competence.

Stage 1 - Non-azotaemic renal disease 2 - Mild renal azotaemia 3 - Moderate renal azotaemia 4 - Severe renal azotaemia
Creatinine (mmol/L) <140 140 - 250 251-440 440
Clinical signs None +/- inappetence, weight loss, PU/PD inappetence, weight loss, PU/PD uraemia, clinically ill
Progression Stable for long periods Stable for long periods May progress Fragile
Therapeutic goals Identify any disease, e.g. pyelonephritis, nephrolithiasis Identify any disease, e.g. pyelonephritis, nephrolithiasis phosphorus restriction, omega-3 fatty acids supplements protein restriction, anti-emetics, erythropoietin, appetite stimulants, SQ fluid supplements, peritoneal dialysis
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