Feline neuroendocrine epithelial tumors

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Feline hepatic tumours arising from the neuroendocrine epithelium of hepatic and biliary tissues have been reported in the cat.

The average age is 9 years, and males are overrepresented. The clinical signs are similar to those seen with other hepatobiliary diseases; however, less than 30% of cats have a palpable abdominal mass.

More than 50% of cats with biliary neuroendocrine tumors are icteric, with elevations in AST, ALP, and ALT activities. Conversely, cats with hepatic neuroendocrine tumors rarely have marked biochemical changes.

Treatment for feline neuroendocrine tumors remains anecdotal, but attempted surgical resection has been reported. In one study, more than 80% of cats died or were euthanized soon after surgery. Metastasis—most often involving the lymph nodes, lungs, or intestines or with evidence of peritoneal carcinomatosis—was identified in all the cats in which necropsy information was available[1].

References

  1. Ferreira-Neves P, et al (2008) Immunohistochemical characterization of a hepatic neuroendocrine carcinoma in a cat. J Vet Diagn Invest 20(1):110-4
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